The molecular physiology of CRAC channels
نویسندگان
چکیده
منابع مشابه
Molecular physiology of oxygen-sensitive potassium channels.
Physiological adaptation to acute hypoxia involves oxygen-sensing by a variety of specialized cells including carotid body type I cells, pulmonary neuroepithelial body cells, pulmonary artery myocytes and foetal adrenomedullary chromaffin cells. Hypoxia induces depolarization by closing a specific set of potassium channels and triggers cellular responses. Molecular biology strategies have recen...
متن کاملMolecular basis of the CRAC channel.
Ca(2+) release-activated Ca(2+) (CRAC) channels, located in the plasma membrane, are opened upon release of Ca(2+) from intracellular stores, permitting Ca(2+) entry and sustained [Ca(2+)](i) signaling that replenishes the store in numerous cell types. This mechanism is particularly important in T lymphocytes of the immune system, providing the missing link in the signal transduction cascade th...
متن کاملOn the stoichiometry of resting and activated CRAC channels.
STIM1 and Orai1 are two essential components of the calcium release-activated calcium (CRAC) channel. Recently, distinct stoichiometries of STIM1 to Orai1 in assembling CRAC channels are proposed based on different techniques, such as single-molecule bleaching, biochemistry, crystallography, and concatenated constructs for electrophysiological experiments. Here, we review in detail these experi...
متن کامل(CRAC) Channels in Human T Cells
Although the crucial role of Ca 2 1 influx in lymphocyte activation has been well documented, little is known about the properties or expression levels of Ca 2 1 channels in normal human T lymphocytes. The use of Na 1 as the permeant ion in divalent-free solution permitted Ca 2 1 release-activated Ca 2 1 (CRAC) channel activation, kinetic properties, and functional expression levels to be inves...
متن کاملWhat keeps Kv channels small? The molecular physiology of modesty
C o m m e n t a r y All known K + channels use the same molecular architecture to achieve K + selectivity. Selectivity filters, even from distantly related K + channels, appear nearly identical in atomic resolution crystal structures; remarkably, the deviation in the coordinates of K +-coordinating backbone carbonyls is less than the uncertainty in the mod-Brohawn et al., 2012). Although retain...
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ژورنال
عنوان ژورنال: Immunological Reviews
سال: 2009
ISSN: 0105-2896,1600-065X
DOI: 10.1111/j.1600-065x.2009.00820.x